Pat shrimp dry and toss with olive oil, chili powder, garlic powder, salt, and pepper.
Heat a large skillet over medium-high heat and sear shrimp 2–3 minutes per side until pink and cooked through. Remove and set aside.
In the same skillet, add butter, garlic, lime juice, lime zest, chili flakes, and sweetener. Stir until melted and combined.
Return shrimp to the skillet and toss in the chili-lime sauce.
In a separate pan, heat olive oil and lightly sauté zoodles with salt for 2–3 minutes until just softened.
Divide zoodles into bowls and top with chili-lime shrimp.
Garnish with cilantro and lime wedges. Serve immediately.